Cytotoxic xanthone–anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022)
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چکیده
منابع مشابه
Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.
A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC(50) value of 1 was moderate, rang...
متن کاملPeptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities.
As part of an ongoing investigation of filamentous fungi for anticancer leads, an active culture was identified from the Mycosynthetix library (MSX 70741, of the order Hypocreales, Ascomycota). The fungal extract exhibited cytotoxic activity against the H460 (human nonsmall cell lung carcinoma) cell line, and bioactivity-directed fractionation yielded peptaibols 1-12 and harzianums A (13) and B...
متن کاملCyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).
Two new cyclodepsipeptides (1 and 2), two new sesquiterpenoids (3 and 4), and the known compounds guangomide A (5), roseotoxin S, and three simple trichothecenes were isolated from the cytotoxic organic extract of a terrestrial filamentous fungus, Trichothecium sp. The structures were determined using NMR spectroscopy and mass spectrometry. Absolute configurations of the cyclodepsipeptides were...
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رابطه ی میانِ هنر و شرایطِ اجتماعیِ زایش آن همواره در طولِ تاریخ دغدغه ی ذهنی و دل مشغولیِ اساسیِ منتقدان و نیز هنرمندان بوده است. از آنجا که هنر در قفس آهنیِ زندگیِ اجتماعی محبوس است، گسترش وابستگیِ آن با نهاد ها و اصولِ اجتماعی پیرامون، صرفِ نظر از هم سو بودن و یا غیرِ هم سو بودنِ آن نهاد ها، امری اجتناب ناپذیر به نظر می رسد. با این وجود پدیدار گشتنِ چنین مباحثِ حائز اهمییتی در میان منتقدین، با ظهورِ مکتب ما...
Cytotoxic and antibacterial naphthoquinones from an endophytic fungus, Cladosporium sp.
OBJECTIVE Endophytes have the potential to synthesize various bioactive secondary metabolites. The aim of the study was to find new cytotoxic and antibacterial metabolites from endophytic fungus, Cladosporium sp. isolated from the leaves of Rauwolfia serpentina (L.) Benth. ex Kurz. (Fam: Apocyanaceae). MATERIALS AND METHODS The endophytic fungus was grown on potato dextrose agar medium and ex...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2011
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2011.95